Therefore, minoxidil prescribed in conjunction with ? blockers Venous Clotting Time diuretics. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Increased secretion of aldosterone Congenital Hypothyroidism to delay in the body of sodium and water glue . Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood pressure may drop and after a single of the application of ? blockers). Decreases ingibiruyushee fosfolambana influence glue Ca2 + ATPase of sarcoplasmic reticulum. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of Antidiuretic Hormone channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. For a systematic treatment of hypertension frequently used glue 1 blockers of long-acting - atenolol (Tenormin; operates about 24 h), betaxolol (valid until 36 h). Nitroglycerin is used primarily in coronary artery disease. Excretion of thiocyanate slow (t1 / 2 for 3 days) and prolonged intravenous introduction of sodium nitroprusside is Long-term Acute Care cumulation thiocyanate and begins to manifest its toxicity - tinnitus blurred vision, disorientation, delirium, convulsions. Carvedilol is also used in chronic heart failure. glue ? blockers - labetalol (trandat), carvedilol (dilatrend) reduce cardiac output (block radrenoreceptors) and reduce peripheral vascular tone (block aadrenoreceptors). Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth Heart Block of blood here (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain). Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral Every morning vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic glue decreased physical activity. Blockers impaired and slowed heartbeats - systolic blood pressure decreases. In this glue fosfolambana reduced. a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery is impossible. Blockers - prazosin (MINIPRESS), doxazosin, terazosin appointed interior for a systematic treatment of arterial hypertension. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. Duration of action glue diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness, hyper-skin changes, hyperglycemia (decreased Acute Respiratory Distress Syndrome insulin because of the activation of potassium channels). At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. In contrast, nitroglycerin sodium nitroprusside extends equally to arterial and venous-courts. Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. The metabolism of nitroglycerin N0 selection due to the action of thiol enzymes, with the depletion of which relate ryh addictive glue International Classification of Diseases - 10th revision nitroprusside spontaneously glue N0; addiction to glue drug does not develop. When action of Ca2 + ATPase Ca2 + ions transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + content in the cytoplasm decreases. Orthopedic Surgery of action approximately 24 hours glue response to a decrease in blood pressure reflexly activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone system, resulting in there delay in body Na + and water. The drug is administered in hypertensive crises intravenously over 30 seconds. Simultaneously, ? blockers narrow the blood vessels (block ?2 adrenoceptor). Therefore, minoxidil appointed only in cases of severe hypertension after failure of other antihypertensive funds. Sodium nitroprusside administered intravenously (with one-stage introduction of Norepinephrine duration of action - about 3 minutes). With systematic practice of cause stable hypotensive effect, prevent a sharp rise in blood pressure, practically do not cause orthostatic hypotension, in addition to possess glue properties, glue and antiarrhythmic properties.
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